3-(4-Hydroxy-3-Methoxyphenyl)Prop-2-Enoic Acid → HCID 11185931、化合物

HRID 476205

反応式

HRID 476205 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][C:13]=1[OH:14])[CH:6]=[CH:7][C:8]([OH:10])=[O:9].N1C=CN=C1.[Si:20](Cl)([C:23]([CH3:26])([CH3:25])[CH3:24])([CH3:22])[CH3:21]>CN(C)C=O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][C:13]=1[O:14][Si:20]([C:23]([CH3:26])([CH3:25])[CH3:24])([CH3:22])[CH3:21])/[CH:6]=[CH:7]/[C:8]([OH:10])=[O:9]

参加物

5

反応物 3

HCID 7093-(4-Hydroxy-3-Methoxyphenyl)Prop-2-Enoic AcidHCID 795ImidazoleHCID 28928tert-Butyldimethylsilyl chloride

生成物 1

HCID 11185931HCID 11185931、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

3-methoxy-4-hydroxy-cinnamic acid (8 g, 41.2 mmol) and imidazole (8.4 g, 123.6 mmol) were charged in a 500 mL round-bottom flask and dissolved in 30 mL of dimethylformamide. Tert-butyldimethylsilyl chloride (13.04 g, 86.5 mmol) was added thereto at 0° C., followed by stirring for 30 minutes. The reaction liquid was concentrated by distillation under reduced pressure and dichloromethane (200 mL) was added thereto, followed by washing with water.

後処理

  1. customat 0° C.
  2. customThe reaction liquid
  3. concentrationwas concentrated by distillation under reduced pressure and dichloromethane (200 mL)
  4. additionwas added
  5. washby washing with water

出典と根拠

ORDレコード
ord-9708da531eec436384af84a96007e043
出典データセット
uspto-grants-2014_01
特許番号
US08637674B2

関連ノート

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