Sodium Sulfite → Sodium 3-trifluoromethylbenzylsulfonate

HRID 476517ノート

反応式

HRID 476517 の反応式
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6]Cl.[S:13]([O-:16])([O-:15])=[O:14].[Na+:17].[Na+]>O>[F:1][C:2]([F:12])([F:11])[C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH2:6][S:13]([O-:16])(=[O:15])=[O:14].[Na+:17]

参加物

4

反応物 2

HCID 24437Sodium SulfiteHCID 697163-(Trifluoromethyl)benzyl chloride

生成物 1

HCID 23700704Sodium 3-trifluoromethylbenzylsulfonate収率 90.5%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture containing 50 g of 3-trifluoromethylbenzyl chloride and 32.4 g of sodium sulfite in 200 ml of water was refluxed for five hours and then concentrated by evaporation. The concentrate was then filtered to collect the precipitate (product). The precipitate was then washed with ethyl ether and then dried in a vacuum oven affording 61 g of sodium 3-trifluoromethylbenzylsulfonate.

後処理

  1. temperaturewas refluxed for five hours
  2. concentrationconcentrated by evaporation
  3. filtrationThe concentrate was then filtered
  4. customto collect the precipitate (product)
  5. washThe precipitate was then washed with ethyl ether
  6. customdried in a vacuum oven

出典と根拠

ORDレコード
ord-3035ba2ef0a1410d9769ed450dd25250
出典データセット
uspto-grants-1989_12
特許番号
US04885027

反応ノート

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