Flavanone → 3(3-Acetylaminobenzylidene)-flavanone

HRID 476606

反応式

HRID 476606 の反応式
[O:1]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:4](=[O:5])[CH2:3][CH:2]1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[C:18]([NH:21][C:22]1[CH:23]=[C:24]([CH:27]=[CH:28][CH:29]=1)[CH:25]=O)(=[O:20])[CH3:19]>N1CCCCC1.C(Cl)(Cl)Cl>[C:18]([NH:21][C:22]1[CH:23]=[C:24]([CH:27]=[CH:28][CH:29]=1)[CH:25]=[C:3]1[C:4](=[O:5])[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[O:1][CH:2]1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)(=[O:20])[CH3:19]

参加物

5

反応物 2

HCID 10251FlavanoneHCID 256849N-(3-formylphenyl)acetamide

生成物 1

HCID 544909013(3-Acetylaminobenzylidene)-flavanone

試薬・触媒・溶媒 2

HCID 8082Piperidine触媒HCID 6212Chloroform溶媒

実験手順

A solid mixture of 9 g flavanone, 7.2 g 3-acetylaminobenzaldehyde and 5 drops piperidine is heated at 150°-160° C. for 3 hours. After allowing to cool, the crude brown glass is dissolved in chloroform and eluted from silicagel with chloroform. The pale yellow oil, obtained on evaporation of the solvent is crystallized from hexane and ethyl acetate to give 3(3-acetylaminobenzylidene)-flavanone as a cream coloured solid; m.p. 172°-173° C.

後処理

  1. temperatureis heated at 150°-160° C. for 3 hours
  2. temperatureto cool
  3. washeluted from silicagel with chloroform
  4. customThe pale yellow oil, obtained on evaporation of the solvent
  5. customis crystallized from hexane and ethyl acetate

出典と根拠

ORDレコード
ord-a9263f90fdaa436fa0e4abe4c0c2c154
出典データセット
uspto-grants-1989_12
特許番号
US04885298

関連ノート

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