Methyl iodide → HCID 14405656、化合物

HRID 476628ノート

反応式

HRID 476628 の反応式
[I:1][CH3:2].[N:3]1[CH:8]=[CH:7][C:6]([C:9]([N:11]2[CH2:20][CH2:19][C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH2:12]2)=[O:10])=[CH:5][CH:4]=1>C(OCC)(=O)C>[I-:1].[CH3:2][N+:3]1[CH:4]=[CH:5][C:6]([C:9]([N:11]2[CH2:20][CH2:19][C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH2:12]2)=[O:10])=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 6328Methyl iodideHCID 4137929HCID 4137929、化合物

生成物 1

HCID 14405656HCID 14405656、化合物収率 86.6%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

2 ml, equivalent to 4.26 g (30.2 mmol) of iodomethane and 6 g (25.2 mmol) of 2-[(4-pyridyl)carbonyl]1,2,3,4-tetrahydroisoquinoline are introduced into 200 ml of ethyl acetate, and the mixture is stirred for 24 h at room temperature. A yellow precipiatate forms, which is filtered off and washed with ether. 8.3 g of product are obtained, this being used without further treatment in the following stage.

後処理

  1. filtrationA yellow precipiatate forms, which is filtered off
  2. washwashed with ether

出典と根拠

ORDレコード
ord-15375fffbed04b289a3feccb6c476305
出典データセット
uspto-grants-1989_12
特許番号
US04885302

反応ノート

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