Cyclopentanol → HCID 19838069、化合物
反応式
[OH:1][CH:2]1[NH:6][C:5](=[O:7])[CH:4]=[CH:3]1.[CH:8]1(O)[CH2:12][CH2:11][CH2:10][CH2:9]1>>[CH:8]1([O:1][CH:2]2[NH:6][C:5](=[O:7])[CH:4]=[CH:3]2)[CH2:12][CH2:11][CH2:10][CH2:9]1参加物
3
反応条件
- 温度
- 60 °C
実験手順
A mixture of 4.5 g of 1,5-dihydro-5-hydroxy-2H-pyrrol-2-one, 100 cm3 of cyclopentanol and 2.25 g of Amberlite IR 120 H is maintained for 8 hours at 60° C. It is then allowed to cool, is filtered, and evaporated to dryness. The residue is chromatographed on silica (eluent: ethyl acetate-n-hexane, 1--1). 3 g of the expected product is obtained, m.p.=77°-78° C. crystallized from cyclohexane. After recrystallizing from a mixture of isopropyl ether-n-hexane, 1--1, m.p.=81°-82° C.
後処理
- temperatureto cool
- filtrationis filtered
- customevaporated to dryness
- customThe residue is chromatographed on silica (eluent: ethyl acetate-n-hexane, 1--1)
出典と根拠
- ORDレコード
- ord-4f261d3d0f1d435d9d465e96d36835f4
- 出典データセット
- uspto-grants-1989_12
- 特許番号
- US04885307
反応ノート
読み込み中…