Hydrochloric Acid → N-[2-(Cyclohexyloxy)phenyl]methanesulfonamide

HRID 476735

反応式

HRID 476735 の反応式
[CH:1]1([O:7][C:8]2[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=2[NH2:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:15][S:16](Cl)(=[O:18])=[O:17].Cl>N1C=CC=CC=1>[CH:1]1([O:7][C:8]2[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=2[NH:10][S:16]([CH3:15])(=[O:18])=[O:17])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 31297Methanesulfonyl chlorideHCID 14771305HCID 14771305、化合物

生成物 1

HCID 14771306N-[2-(Cyclohexyloxy)phenyl]methanesulfonamide収率 89.4%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

To 20 ml of a pyridine solution containing 2.7 g of 2-cyclohexyloxyaniline was added dropwise 1.8 g of methanesulfonyl chloride under ice cooling with stirring. After completion of the addition, the mixture was stirred at room temperature for 2 hours. The reaction solution was poured into ice water and made acidic with dilute hydrochloric acid. The crystals which formed were collected by filtration, washed with water and dried to give 3.8 g of the crude crystals, which were then recrystallized from ethanol-n hexane to give 3.4 g of N-(2-cyclohexyloxyphenyl)methanesulfonamide.

後処理

  1. additionAfter completion of the addition
  2. stirringthe mixture was stirred at room temperature for 2 hours
  3. customThe crystals which formed
  4. filtrationwere collected by filtration
  5. washwashed with water
  6. customdried
  7. customto give 3.8 g of the crude crystals, which
  8. customwere then recrystallized from ethanol-n hexane

出典と根拠

ORDレコード
ord-d60f411f1bd84b318eff2566602610b7
出典データセット
uspto-grants-1989_12
特許番号
US04885367

関連ノート

読み込み中…