Thionyl Chloride → 1-(Chloromethyl)-4-(methylthio)benzene

HRID 476806

反応式

HRID 476806 の反応式
[CH3:1][S:2][C:3]1[CH:10]=[CH:9][C:6]([CH2:7]O)=[CH:5][CH:4]=1.S(Cl)([Cl:13])=O>C1C=CC=CC=1>[CH3:1][S:2][C:3]1[CH:10]=[CH:9][C:6]([CH2:7][Cl:13])=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 24386Thionyl Chloride3 回HCID 592968[4-(Methylsulfanyl)phenyl]methanol

生成物 1

HCID 701281-(Chloromethyl)-4-(methylthio)benzene

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

To a stirred solution of 154 g (1 mol) of 4-methylmercaptobenzyl alcohol in 1 liter of dry bensene was added dropwise 80 ml 1.1 mol) of thionyl chloride. The mixture immediately turned blue. After the addition of the thionyl chloride was completed, the mixture was heated at reflux for 2 hours. After cooling the benzene and excess thionyl chloride were distilled at ambient pressure. The product was distilled in vacuo at 105° C. (0.5 mm), to yield 160 g (93%) of water clear liquid.

後処理

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 2 hours
  3. distillationwere distilled at ambient pressure
  4. distillationThe product was distilled in vacuo at 105° C. (0.5 mm)
  5. customto yield 160 g (93%) of water clear liquid

出典と根拠

ORDレコード
ord-71b67db3caa84f5ab4f60163f6044328
出典データセット
uspto-grants-1989_12
特許番号
US04886339

関連ノート

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