Tetrahydrofuran → Ethyl 4-[2-(1H-indol-3-yl)-ethyl]-3-oxo-1-(1-oxododecyl)-2-piperazine acetate

HRID 476882

反応式

HRID 476882 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][NH:15][CH:14]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[C:13]2=[O:24])=[CH:2]1.C(N(CC)CC)C.[CH2:32](Cl)[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH3:43].[O:45]1CCCC1>>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][N:15]([C:32](=[O:45])[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH3:43])[CH:14]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[C:13]2=[O:24])=[CH:2]1

参加物

5

反応物 4

HCID 8028TetrahydrofuranHCID 81921-ChlorododecaneHCID 8471TriethylamineHCID 14257258Ethyl 4-[2-(1H-indol-3-yl)-ethyl]-3-oxo-2-piperazine acetate

生成物 1

HCID 70378265Ethyl 4-[2-(1H-indol-3-yl)-ethyl]-3-oxo-1-(1-oxododecyl)-2-piperazine acetate

実験手順

2.14 g of the product of Step C of Example 1 were dissolved in a mixture containing 1.4 ml of triethylamine and 25 ml of tetrahydrofuran. 1.5 ml of lauryl chloride were added dropwise and after stirring for 30 minutes, the precipitate was filtered off. The filtrate was concentrated to dryness and the residue was taken up in methylene chloride, washed with water and dried. The solvent was eliminated under reduced pressure at 50° C. to obtain 3.2 g of the expected product.

後処理

  1. filtrationthe precipitate was filtered off
  2. concentrationThe filtrate was concentrated to dryness
  3. washwashed with water
  4. customdried
  5. customwas eliminated under reduced pressure at 50° C.

出典と根拠

ORDレコード
ord-bd0dc14117b6432784458830487d75c4
出典データセット
uspto-grants-1989_12
特許番号
US04886802

関連ノート

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