反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8]([C:10]1[NH:11][C:12]2[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=2[N:14]=1)=[O:9].[H-].[Na+].[CH3:21][N:22]([CH3:26])[CH2:23][CH2:24]Cl.[Cl-].[NH4+]>CS(C)=O>[CH3:21][N:22]([CH3:26])[CH2:23][CH2:24][N:14]1[C:13]2[CH:15]=[CH:16][CH:17]=[CH:18][C:12]=2[N:11]=[C:10]1[C:8]([NH:7][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1)=[O:9]参加物
6
実験手順
N-(2-pyridyl)benzimidazole-2-carboxamide (2.0 g) prepared in Example 1 was dissolved in dry DMSO (25 ml), sodium hydride (0.35 g) was added and stirred at room temperature for 1 hr. Excess β-dimethylaminoethyl chloride was added to the mixture and allowed to react overnight at room temperature under agitation. The reaction solution was poured into aqueous saturated ammonium chloride solution and extracted with chloroform. The chloroform layer was dried over anhydrous Na2SO4 and the solvent was distilled off. Purification of the residue by column chromatography on silica gel gave the title compound (0.84 g).
後処理
- customto react overnight at room temperature under agitation
- extractionextracted with chloroform
- dry with materialThe chloroform layer was dried over anhydrous Na2SO4
- distillationthe solvent was distilled off
- customPurification of the residue by column chromatography on silica gel
出典と根拠
- ORDレコード
- ord-d86dc80316844185b931bc596695868e
- 出典データセット
- uspto-grants-1989_12
- 特許番号
- US04886803
関連ノート
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