Sodium hydride → N-(2-Pyridyl)-1-[2-(4-(3,4-dimethoxybenzoyl)-1-piperazinyl)ethyl]-5,6-dimethoxybenzimidazole-2-carboxamide

HRID 476898

反応式

HRID 476898 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8]([C:10]1[NH:11][C:12]2[CH:18]=[C:17]([O:19][CH3:20])[C:16]([O:21][CH3:22])=[CH:15][C:13]=2[N:14]=1)=[O:9].[H-].[Na+].[CH3:25][O:26][C:27]1[CH:28]=[C:29]([CH:41]=[CH:42][C:43]=1[O:44][CH3:45])[C:30]([N:32]1[CH2:37][CH2:36][N:35]([CH2:38][CH2:39]Cl)[CH2:34][CH2:33]1)=[O:31]>CS(C)=O>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8]([C:10]1[N:11]([CH2:39][CH2:38][N:35]2[CH2:36][CH2:37][N:32]([C:30](=[O:31])[C:29]3[CH:41]=[CH:42][C:43]([O:44][CH3:45])=[C:27]([O:26][CH3:25])[CH:28]=3)[CH2:33][CH2:34]2)[C:12]2[CH:18]=[C:17]([O:19][CH3:20])[C:16]([O:21][CH3:22])=[CH:15][C:13]=2[N:14]=1)=[O:9]

参加物

5

反応物 3

HCID 24758Sodium hydrideHCID 118091532-[4-(3,4-Dimethoxybenzoyl)-1-piperazinyl]ethyl chlorideHCID 19837066N-(2-pyridyl)-5,6-dimethoxybenzimidazole-2-carboxamide

生成物 1

HCID 14371293N-(2-Pyridyl)-1-[2-(4-(3,4-dimethoxybenzoyl)-1-piperazinyl)ethyl]-5,6-dimethoxybenzimidazole-2-carboxamide収率 44%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒2 回

実験手順

In an argon atmosphere, N-(2-pyridyl)-5,6-dimethoxybenzimidazole-2-carboxamide (0.85 g) was dissolved in DMSO (15 ml), and 60% sodium hydride (0.16 g) was added and stirred at room temperature for 1 hr. A solution (5 ml) of 2-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]ethyl chloride (1.25 g) in DMSO was added dropwise and allowed to react overnight at room temperature under agitation. After-treatment and purification in the same manner as described in Example 14 gave the title compound (0.72 g) as amorphous solid.

後処理

  1. customto react overnight at room temperature under agitation
  2. customAfter-treatment and purification in the same manner

出典と根拠

ORDレコード
ord-2f436732b9d94704a5febb0c7011db82
出典データセット
uspto-grants-1989_12
特許番号
US04886803

関連ノート

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