反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8]([C:10]1[NH:11][C:12]2[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=2[N:14]=1)=[O:9].[H-].[Na+].[CH3:21][O:22][C:23]1[CH:24]=[C:25]([CH:37]=[CH:38][C:39]=1[O:40][CH3:41])[C:26]([N:28]1[CH2:33][CH2:32][N:31]([CH2:34][CH2:35]Cl)[CH2:30][CH2:29]1)=[O:27].[Cl-].[NH4+]>CS(C)=O>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8]([C:10]1[N:11]([CH2:35][CH2:34][N:31]2[CH2:32][CH2:33][N:28]([C:26](=[O:27])[C:25]3[CH:37]=[CH:38][C:39]([O:40][CH3:41])=[C:23]([O:22][CH3:21])[CH:24]=3)[CH2:29][CH2:30]2)[C:12]2[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=2[N:14]=1)=[O:9]参加物
6
反応物 4
生成物 1
試薬・触媒・溶媒 1
実験手順
In an argon atmosphere, N-(2-pyridyl)benzimidazole-2-carboxamide (1.40 g) was dissolved in DMSO (20 ml), and 60% sodium hydride (0.28 g) was added and stirred at room temperature for 1 hr. A solution (7 ml) of 2-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]ethyl chloride (1.90 g) in DMSO was added dropwise and allowed to react overnight at room temperature under agitation. The reaction solution was poured into an aqueous solution of ammonium chloride and extracted with chloroform. The chloroform layer was dried over Na2SO4 and the solvent was distilled off. Purification of the residue by column chromatography on silica gel gave the title compound (1.60 g) as amorphous solid.
後処理
- customto react overnight at room temperature under agitation
- extractionextracted with chloroform
- dry with materialThe chloroform layer was dried over Na2SO4
- distillationthe solvent was distilled off
- customPurification of the residue by column chromatography on silica gel
出典と根拠
- ORDレコード
- ord-69740c2500544e618dec4d0230f5d979
- 出典データセット
- uspto-grants-1989_12
- 特許番号
- US04886803
関連ノート
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