Carbon Disulfide → HCID 178506204、化合物

HRID 476903ノート

反応式

HRID 476903 の反応式
[C:1](=[S:3])=S.[F:4][C:5]([F:15])([F:14])[C:6]1[C:7]([NH:12][NH2:13])=[N:8][CH:9]=[CH:10][CH:11]=1>N1C=CC=CC=1>[SH:3][C:1]1[N:8]2[CH:9]=[CH:10][CH:11]=[C:6]([C:5]([F:15])([F:14])[F:4])[C:7]2=[N:12][N:13]=1

参加物

4

反応物 2

HCID 6348Carbon DisulfideHCID 27777762-Hydrazinyl-3-(trifluoromethyl)pyridine

生成物 1

HCID 178506204HCID 178506204、化合物

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

16 ml of carbon disulfide are added dropwise at room temperature, with stirring, to a suspension of 40 g of 3-trifluoromethyl-2-hydrazinopyridine, prepared in Example 12, in 75 ml of pyridine. When the additioon is complete, stirring is continued for 15 minutes at room temperature and the reaction mixture is then heated under reflux for 5 hours. After cooling, the medium is concentrated in vacuo and water is then added. The solid residue obtained is filtered off, washed with water and dried to give 40 g of 3-mercapto-8-trifluoromethyl-1,2,4-triazolo(4,3-a)pyridine in the form of crystals melting at 236° C.

後処理

  1. temperaturethe reaction mixture is then heated
  2. temperatureunder reflux for 5 hours
  3. temperatureAfter cooling
  4. concentrationthe medium is concentrated in vacuo and water
  5. additionis then added
  6. customThe solid residue obtained
  7. filtrationis filtered off
  8. washwashed with water
  9. customdried

出典と根拠

ORDレコード
ord-a55edcc8dff24222a6a3944319a25426
出典データセット
uspto-grants-1989_12
特許番号
US04886805

反応ノート

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