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Methyl iodide → 4-[N-(4-Chloro-benzyl)-methylamino]-cyclohexanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-[N-(4-Chloro-benzyl)-amino]-cyclohexanone | HCID 13670664 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-[N-(4-Chloro-benzyl)-methylamino]-cyclohexanone | HCID 13670665 | — |
反応手順
8.4 g (35 mMol) of 4-[N-(4-chloro-benzyl)-amino]-cyclohexanone are dissolved in 50 ml of absolute dimethylformamide and, after the addition of 2.6 g (18.7 mMol) of potassium carbonate, 5.0 g (35 mMol) of methyliodide are added dropwise at 25°-30° C. After standing overnight the mixture is concentrated, mixed with water and extracted with chloroform. The extracts are dried and concentrated.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04886812 |
| 出典データセット | uspto-grants-1989_12 |
| ORD ID | ord-b44f2a8493cb4e228d3776ff9a6419de |
| 出典メモ | uspto-grants-1989_12 |