Ammonia → 4-Thiazolemethanol, alpha-(bromomethyl)-2-(trifluoromethyl)-

HRID 477086ノート

反応式

HRID 477086 の反応式
[F:1][C:2]([F:13])([F:12])[C:3]1[S:4][CH:5]=[C:6]([C:8](=[O:11])[CH2:9][Br:10])[N:7]=1.[BH4-].[Na+].Cl.N>CO>[F:13][C:2]([F:1])([F:12])[C:3]1[S:4][CH:5]=[C:6]([CH:8]([OH:11])[CH2:9][Br:10])[N:7]=1

参加物

6

反応物 4

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 10978660HCID 10978660、化合物

生成物 1

HCID 222204994-Thiazolemethanol, alpha-(bromomethyl)-2-(trifluoromethyl)-

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
10 °C

実験手順

6 g (0.022 mol) of 2-Trifluoromethyl-4-bromoacetyl-thiazole are dissolved in 150 ml of methanol, and the solution is cooled to 10° C. and 0.63 g of sodium borohydride is added. After 15 minutes ice is added, and the mixture is acidified with hydrochloric acid, made alkaline with ammonia and extracted by shaking with methylene chloride. The organic phase is dried over sodium sulphate, filtered and concentrated. An oil is obtained and is reacted further as the crude product.

後処理

  1. additionAfter 15 minutes ice is added
  2. extractionextracted
  3. dry with materialThe organic phase is dried over sodium sulphate
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customAn oil is obtained

出典と根拠

ORDレコード
ord-3a54d529ba3746babc35a3b2bbf99975
出典データセット
uspto-grants-1989_12
特許番号
US04886814

反応ノート

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