Sodium Hydroxide → 2-(2-Trifluoromethyl-thiazol-4-yl)ethylene oxide
反応式
[F:1][C:2]([F:13])([F:12])[C:3]1[S:4][CH:5]=[C:6]([CH:8]([OH:11])[CH2:9]Br)[N:7]=1.[OH-].[Na+]>>[F:1][C:2]([F:13])([F:12])[C:3]1[S:4][CH:5]=[C:6]([CH:8]2[O:11][CH2:9]2)[N:7]=1参加物
3
実験手順
5 g (0.018 mol) of 1-(2-Trifluoromethyl-thiazol-4-yl)-1-hydroxy-2-bromoethane are suspended in 4 ml of 50% strength sodium hydroxide solution and stirred for 5 minutes. The mixture is then diluted with ice-water and extracted by shaking with methylene chloride. The organic phase is dried over sodium sulphate and concentrated in vacuo at 20° C., and the resulting oil is purified on a silica gel column using methylene chloride as eluant.
後処理
- extractionextracted
- stirringby shaking with methylene chloride
- dry with materialThe organic phase is dried over sodium sulphate
- concentrationconcentrated in vacuo at 20° C.
- customthe resulting oil is purified on a silica gel column
出典と根拠
- ORDレコード
- ord-6acb9b42941e4d3e8a47593b04865ac5
- 出典データセット
- uspto-grants-1989_12
- 特許番号
- US04886814
反応ノート
読み込み中…