Malonic Acid → 3-(5-Cyano-2-thiophenyl)-propenoic acid

HRID 477171

反応式

HRID 477171 の反応式
[C:1]([C:3]1[S:7][C:6]([CH:8]=O)=[CH:5][CH:4]=1)#[N:2].C(O)(=O)[CH2:11][C:12]([OH:14])=[O:13]>N1C=CC=CC=1.N1CCCCC1>[C:1]([C:3]1[S:7][C:6]([CH:8]=[CH:11][C:12]([OH:14])=[O:13])=[CH:5][CH:4]=1)#[N:2]

参加物

5

反応物 2

HCID 867Malonic Acid2 回HCID 122800045-Formylthiophene-2-Carbonitrile

生成物 1

HCID 679354333-(5-Cyano-2-thiophenyl)-propenoic acid

試薬・触媒・溶媒 2

HCID 1049Pyridine溶媒HCID 8082Piperidine溶媒

実験手順

A stirred solution of 5-cyano-2-thiophene carboxaldehyde (3.3 g) and malonic acid (2.5 g) in pyridine (35 ml) and piperidine (0.7 ml) was heated under reflux for 2 hours adding further malonic acid (1.3 g) after 1 hour. The solution was evaporated and the residue was stirred with M hydrochloric acid solution (100 ml) to give a pale solid which was washed with water and dried, m.p. ca 260° C. (subliming).

後処理

  1. temperatureunder reflux for 2 hours
  2. customThe solution was evaporated
  3. customto give a pale solid which
  4. washwas washed with water
  5. customdried

出典と根拠

ORDレコード
ord-5974a54b8de34cc1931a9ce2ebd93e8e
出典データセット
uspto-grants-1989_12
特許番号
US04886885

関連ノート

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