Water → HCID 11791018、化合物
反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[C:11](=[O:12])[C:10]3[CH:13]=[CH:14][CH:15]=[CH:16][C:9]=3[CH2:8][O:7][C:6]=2[CH:17]=1.[BH4-].[Na+].O>CO>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[CH:11]([OH:12])[C:10]3[CH:13]=[CH:14][CH:15]=[CH:16][C:9]=3[CH2:8][O:7][C:6]=2[CH:17]=1参加物
5
実験手順
To a solution of 2.0 g of 3-fluoro-6,11-dihydrodibenz[b,e]oxepin-11-one in 20 ml of methanol is added 0.5 g of sodium borohydride with ice-cooling and then the mixture is stirred at the same temperature for 1 hour. The reaction mixture is poured into water and the resultant is extracted with toluene. The extract is washed with water and then dried over magnesium sulfate. Toluene is distilled off to give 1.9 g of 3-fluoro-6,11-dihydrodibenz[b,e]oxepin-11-ol (crystals). Mass spectrum m/z: 230(M+).
後処理
- temperaturecooling
- extractionthe resultant is extracted with toluene
- washThe extract is washed with water
- dry with materialdried over magnesium sulfate
- distillationToluene is distilled off
出典と根拠
- ORDレコード
- ord-bbee9ad46f224e4590e569f45ad15f0e
- 出典データセット
- uspto-grants-1989_12
- 特許番号
- US04889858
反応ノート
読み込み中…