Dimethylformamide → Ethyl 3-fluoro-2-methylbenzoate
反応式
[F:1][C:2]1[C:3]([CH3:11])=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([OH:7])=[O:6].CN(C)C=O.C(=O)([O-])[O-].[K+].[K+].[CH2:23](I)[CH3:24]>C1(C)C=CC=CC=1>[F:1][C:2]1[C:3]([CH3:11])=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([O:7][CH2:23][CH3:24])=[O:6]参加物
6
実験手順
To a solution of 10 g of 3-fluoro-2-methylbenzoic acid [J. Org. Chem., 26, 3208 (1961)]in 300 ml of dimethylformamide are added 30 g of potassium carbonate and 30 g of ethyl iodide and the mixture is stirred at room temperature for 8 hours. After adding 500 ml of toluene, washing with water and a saturated saline solution and drying over magnesium sulfate, the solvent is distilled off under reduced pressure to give 11 g of ethyl 3-fluoro-2-methylbenzoate (oil). Mass spectrum m/z: 182(M+).
後処理
- washwashing with water
- dry with materiala saturated saline solution and drying over magnesium sulfate
- distillationthe solvent is distilled off under reduced pressure
出典と根拠
- ORDレコード
- ord-e5a800762539454e9188c5139c31b007
- 出典データセット
- uspto-grants-1989_12
- 特許番号
- US04889858
反応ノート
読み込み中…