N-bromobutanimide → Ethyl 2-(bromomethyl)-3-fluorobenzoate

HRID 477786ノート

反応式

HRID 477786 の反応式
[F:1][C:2]1[C:3]([CH3:13])=[C:4]([CH:10]=[CH:11][CH:12]=1)[C:5]([O:7][CH2:8][CH3:9])=[O:6].[Br:14]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl>[F:1][C:2]1[C:3]([CH2:13][Br:14])=[C:4]([CH:10]=[CH:11][CH:12]=1)[C:5]([O:7][CH2:8][CH3:9])=[O:6]

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 14626272Ethyl 3-fluoro-2-methylbenzoate

生成物 1

HCID 14626273Ethyl 2-(bromomethyl)-3-fluorobenzoate収率 82.5%

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

To a solution of 11 g of ethyl 3-fluoro-2-methylbenzoate in 300 ml of carbon tetrachloride is added 12 g of N-bromosuccinimide and the mixture is refluxed with heating for 12 hours. After cooling, the mixture is washed with water and a saturated saline solution and dried over magnesium sulfate and the solvent is distilled off under reduced pressure to give 13 g of ethyl 3-fluoro-2-bromomethylbenzoate. Mass spectrum m/z: 262, 260(M+).

後処理

  1. temperaturethe mixture is refluxed
  2. temperaturewith heating for 12 hours
  3. temperatureAfter cooling
  4. washthe mixture is washed with water
  5. dry with materiala saturated saline solution and dried over magnesium sulfate
  6. distillationthe solvent is distilled off under reduced pressure

出典と根拠

ORDレコード
ord-44272f909ca047aca1e56cdfa6c427f5
出典データセット
uspto-grants-1989_12
特許番号
US04889858

反応ノート

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