反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.[BrH:12].BrBr>ClC(Cl)(Cl)Cl>[Br:12][CH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:6][CH:7]=1参加物
実験手順
To a stirred solution of p-methylphenylacetic acid (0.175 mol, 27.8 g) in tetrachloromethane (250 mL) under a nitrogen atmosphere in a round bottom flask equipped with a reflux condenser and provision for trapping the released HBr was added bromine (0.175 mol, 27.8 g) dissolved in tetrachloromethane. The red/brown mixture was irradiated and brought to reflux with a 250 watt incandescent light source. Over the course of ten minutes, the color was discharged and a crystalline precipitate was formed. The mixture was allowed to cool to room temperature, and the solid was collected by vacuum filtration, and dried in a stream of nitrogen to give (4-bromomethyl-phenyl)-acetic acid as a white solid containing 6.3% by weight p-methylphenylacetic acid as an impurity. (25.1 g, 63%).
後処理
- customThe red/brown mixture was irradiated
- temperatureto reflux with a 250 watt incandescent light source
- customOver the course of ten minutes
- customa crystalline precipitate was formed
- filtrationthe solid was collected by vacuum filtration
- customdried in a stream of nitrogen
出典と根拠
- ORDレコード
- ord-9555f4d9c8914c59af9dc1e2342d6db4
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06699904B2
関連ノート
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