Thionyl Chloride → HCID 178509760、化合物

HRID 477971

反応式

HRID 477971 の反応式
C([NH:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([CH:14](O)[CH2:15][CH2:16][CH2:17][C:18]2[N:19]=[CH:20][N:21]([Si](C)(C)C)[CH:22]=2)=[CH:10][CH:9]=1)=O)(C)(C)C.S(Cl)([Cl:30])=O>>[Cl:30][CH:14]([C:11]1[CH:12]=[CH:13][C:8]([C:6]#[N:5])=[CH:9][CH:10]=1)[CH2:15][CH2:16][CH2:17][C:18]1[N:19]=[CH:20][NH:21][CH:22]=1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 199304194-[4-(p-tert-Butylaminocarbonylphenyl)-4-hydroxy-n-butyl]-1-trimethylsilylimidazole

生成物 1

HCID 178509760HCID 178509760、化合物

実験手順

A solution of 4.5 g of 4-[4-(p-tert-butylaminocarbonylphenyl)-4-hydroxy-n-butyl]-1-trimethylsilylimidazole in 50 ml of thionyl chloride is refluxed for 1 h, cooled and evaporated. The residue is partitioned between methylene chloride and aqueous sodium bicarbonate solution. The organic phase is separated, dried over sodium sulfate and evaporated to yield the title compound (c).

後処理

  1. temperaturecooled
  2. customevaporated
  3. customThe residue is partitioned between methylene chloride and aqueous sodium bicarbonate solution
  4. customThe organic phase is separated
  5. dry with materialdried over sodium sulfate
  6. customevaporated

出典と根拠

ORDレコード
ord-5fbd31894475459982e5655955531d5c
出典データセット
uspto-grants-1989_12
特許番号
US04889861

関連ノート

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