Hydrochloric Acid → α-[[(1,1-Dimethylethyl)sulfinyl]methyl]benzenepropanoic acid
反応式
C([O:3][C:4](=[O:20])[CH:5]([CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH2:6][S:7]([C:9]([CH3:12])([CH3:11])[CH3:10])=[O:8])C.O.[OH-].[Na+].Cl>CO>[CH2:13]([CH:5]([CH2:6][S:7]([C:9]([CH3:12])([CH3:11])[CH3:10])=[O:8])[C:4]([OH:20])=[O:3])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1参加物
6
実験手順
3.2 g of 2-benzyl-3-tert.-butylsulphinyl-propionic acid ethyl ester are dissolved in 30 ml of methanol, and 30 ml of water and 10.8 ml of 1N sodium hydroxide solution are added thereto. The mixture is stirred at room temperature for 16 hours, neutralised with 10.8 ml of 1N hydrochloric acid and concentrated in vacuo. The residue is purified by flash chromatography on 150 g of silica gel 60 (eluant J). Rf (J)=0.38.