Hydrochloric Acid → 2-Benzyl-3-dimethylaminosulphonyl-propionic acid
反応式
C([O:3][C:4](=[O:20])[CH:5]([CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH2:6][S:7]([N:10]([CH3:12])[CH3:11])(=[O:9])=[O:8])C.CO.[OH-].[Na+].Cl>O>[CH2:13]([CH:5]([CH2:6][S:7]([N:10]([CH3:12])[CH3:11])(=[O:9])=[O:8])[C:4]([OH:20])=[O:3])[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1参加物
6
実験手順
A mixture of 299 mg of 2-benzyl-3-dimethylaminosulphonyl-propionic acid ethyl ester, 1 ml of methanol, 2 ml of water and 0.42 ml of 1H NaOH is stirred for 16 hours at room temperature, then neutralise with 0.42 ml of 1N HCl and extracted with ethyl acetate. The organic extracts are washed with water, dried, concentrated by evaporation and purified by chromatography on silica gel with eluant I. Rf (J)=0.48.
後処理
- extractionextracted with ethyl acetate
- washThe organic extracts are washed with water
- customdried
- concentrationconcentrated by evaporation
- custompurified by chromatography on silica gel with eluant I
出典と根拠
- ORDレコード
- ord-94f9f106ed6b426fad81e5edc64cd89b
- 出典データセット
- uspto-grants-1989_12
- 特許番号
- US04889869
反応ノート
読み込み中…