Dimethylformamide dimethyl acetal → 4-(3-Dimethylamino-acryloyl)-3-methyl-5-methylsulfanylthiophene-2-carbonitrile
反応式
[C:1]([C:4]1[C:5]([CH3:13])=[C:6]([C:11]#[N:12])[S:7][C:8]=1[S:9][CH3:10])(=[O:3])[CH3:2].[CH3:14][N:15]([CH:17](OC)OC)[CH3:16]>C(#N)C>[CH3:14][N:15]([CH3:17])[CH:16]=[CH:2][C:1]([C:4]1[C:5]([CH3:13])=[C:6]([C:11]#[N:12])[S:7][C:8]=1[S:9][CH3:10])=[O:3]参加物
4
実験手順
To a solution of 4-acetyl-3-methyl-5-methylsulfanyl-thiophene-2-carbonitrile (10 mmol) in acetonitrile (5 mL) was added DMF-DMA (2 mL) and the resulting mixture heated at reflux for 18 hours. The reaction was concentrated and the residue triturated with diethyl ether (20 mL). The suspension was filtered and washed with ether to afford the desired product as a yellow solid.
後処理
- temperaturethe resulting mixture heated
- temperatureat reflux for 18 hours
- concentrationThe reaction was concentrated
- customthe residue triturated with diethyl ether (20 mL)
- filtrationThe suspension was filtered
- washwashed with ether
出典と根拠
- ORDレコード
- ord-950cf2324e5e476fbb96a1f067bfa35a
- 出典データセット
- uspto-grants-2003_11
- 特許番号
- US06642227B2
反応ノート
読み込み中…