HCID 178419031、化合物 → HCID 178418735、化合物
反応式
C([O:8][C:9]1[CH:10]=[C:11]([NH:15][C:16]([NH2:18])=[NH:17])[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1>CCO.[Pd]>[OH:8][C:9]1[CH:10]=[C:11]([NH:15][C:16]([NH2:18])=[NH:17])[CH:12]=[CH:13][CH:14]=1参加物
4
実験手順
To a solution of N-(3-benzyloxy-phenyl)guanidine (5.0 g, 20.6 mmol) in EtOH (150 mL) was added palladium on carbon (10%, wet, 50% water, 0.5 g)). The mixture was stirred under hydrogen atmosphere overnight. The reaction was filtered through a plug of celite and the filtrate concentrated in vacuo. with toluene azeotroping to affored the desired material (2.83 g, 91%). 1H NMR (MeOH-d4) δ6.4-7 (m, 4H)
後処理
- filtrationThe reaction was filtered through a plug of celite
- concentrationthe filtrate concentrated in vacuo
出典と根拠
- ORDレコード
- ord-d6c02952b6ab4954bab6ec20e5471e3f
- 出典データセット
- uspto-grants-2003_11
- 特許番号
- US06642227B2
反応ノート
読み込み中…