Sodium Nitrate → 4-Bromo-3-nitrobenzaldehyde

HRID 478288

反応式

HRID 478288 の反応式
[N+:1]([O-:4])([O-])=[O:2].[Na+].[Br:6][C:7]1[CH:14]=[CH:13][C:10]([CH:11]=[O:12])=[CH:9][CH:8]=1>S(=O)(=O)(O)O>[Br:6][C:7]1[CH:14]=[CH:13][C:10]([CH:11]=[O:12])=[CH:9][C:8]=1[N+:1]([O-:4])=[O:2]

参加物

4

反応物 2

HCID 24268Sodium NitrateHCID 707414-Bromobenzaldehyde

生成物 1

HCID 8087924-Bromo-3-nitrobenzaldehyde収率 95%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

反応条件

温度
10 °C

実験手順

A suspension of sodium nitrate (1.37 g, 16.2 mmol) in concentrated sulfuric acid (15 mL) was stirred at 10° C. until a homogeneous solution was obtained. The solution was treated with 4-bromobenzaldehyde (2.50 g, 13.5 mmol) in portionwise fashion over a 20 minute period. The solution was poured onto ice (50 g) and the resulting pale yellow precipitate was collected by filteration. The precipitate was washed with copious amounts of water then dried at 30° C. under reduced pressure to provide the title compound as a pale yellow solid (2.95 g, 12.8 mmol, 95%).

後処理

  1. customwas obtained
  2. additionThe solution was poured onto ice (50 g)
  3. customthe resulting pale yellow precipitate was collected by filteration
  4. washThe precipitate was washed with copious amounts of water
  5. customthen dried at 30° C. under reduced pressure

出典と根拠

ORDレコード
ord-795925d01a8d41a0be58dadcd0128125
出典データセット
uspto-grants-2003_11
特許番号
US06642222B2

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