関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Methyl 4-(4-methylpiperazin-1-yl)benzoate | HCID 1472668 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 4-(4-Methylpiperazin-1-yl)benzoic acid hydrochloride | HCID 18562273 | — |
反応手順
4-(4-Methyl-piperazin-1-yl)-benzoic acid methyl ester (8.5 mmol) is dissolved in 4N HCl (15 ml) and heated under reflux for 8 hours. The mixture is cooled in an ice bath to 0-4° C., diluted with 5 ml acetone and the solid material formed is filtered off, washed with acetone and dried (vacuum). A white powder with mp. >270° C., Rf=0.11 (CH2Cl2/MeOH=9:1) is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06642239B2 |
|---|
| 出典データセット | uspto-grants-2003_11 |
|---|
| ORD ID | ord-e05871aee5d34ade99a6fdea2466975f |
|---|
| 出典メモ | uspto-grants-2003_11 |
|---|
