反应详情

温度

2 °C

4-(4-Methyl-piperazin-1-yl)-benzoic acid methyl ester (8.5 mmol) is dissolved in 4N HCl (15 ml) and heated under reflux for 8 hours. The mixture is cooled in an ice bath to 0-4° C., diluted with 5 ml acetone and the solid material formed is filtered off, washed with acetone and dried (vacuum). A white powder with mp. >270° C., Rf=0.11 (CH2Cl2/MeOH=9:1) is obtained.

1. temperatureheated
2. temperatureunder reflux for 8 hours
3. customthe solid material formed
4. filtrationis filtered off
5. washwashed with acetone
6. customdried (vacuum)
7. customA white powder with mp. >270° C., Rf=0.11 (CH2Cl2/MeOH=9:1) is obtained