4-(4-Benzyl-piperazin-1-YL)-benzoic acid methyl ester → Methyl 4-(piperazin-1-yl)benzoate
反応式
[CH3:1][O:2][C:3](=[O:23])[C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13](CC3C=CC=CC=3)[CH2:12][CH2:11]2)=[CH:6][CH:5]=1.[H][H]>CO.[Pd].C>[CH3:1][O:2][C:3](=[O:23])[C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[CH:8][CH:9]=1参加物
5
実験手順
4-(4-Benzyl-piperazin-1-yl)-benzoic acid methyl ester (19.4 mmol) is dissolved in methanol (150 ml) and Pd/charcoal is added (0.6 g). The mixture is stirred in a hydrogen atmosphere until consumption has ceased. The catalyst is filtered off and the filtrate evaporated. The residue is suspended in diethylether/pentane and the solid filtered of and dried (vacuum). A powder with mp. 95-97° C. is obtained.
後処理
- filtrationThe catalyst is filtered off
- customthe filtrate evaporated
- filtrationthe solid filtered of and
- customdried (vacuum)
- customA powder with mp. 95-97° C. is obtained
出典と根拠
- ORDレコード
- ord-305fc93190cc47c78bc1b9788ef9a944
- 出典データセット
- uspto-grants-2003_11
- 特許番号
- US06642239B2
反応ノート
読み込み中…