Pyridine → HCID 11608128、化合物

HRID 478639ノート

反応式

HRID 478639 の反応式
[C:1]1([CH:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.N1C=CC=CC=1.[C:19](Cl)(=[O:21])[CH3:20]>C(Cl)Cl>[C:1]1([CH:7]2[CH2:8][CH2:9][N:10]([C:19](=[O:21])[CH3:20])[CH2:11][CH2:12]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 1049PyridineHCID 6367Acetyl chlorideHCID 698734-Phenylpiperidine

生成物 1

HCID 11608128HCID 11608128、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

4-Phenylpiperidine (87 mmol) and pyridine (96 mmol) are dissolved in dry CH2Cl2 (100 ml) and acetylchloride (96 mmol) in CH2Cl2 (40 ml) is added dropwise to the stirred solution at 10° C. The reaction is stirred for 1 hour at rt. The mixture is extracted three times with water and the water phase is extracted again with CH2Cl2. The combined organic phases are dried over sodium sulfate and evaporated. A pale brown oil with Rf=0.13 (ethyl acetate/hexane=1:1) is obtained.

後処理

  1. extractionThe mixture is extracted three times with water
  2. extractionthe water phase is extracted again with CH2Cl2
  3. dry with materialThe combined organic phases are dried over sodium sulfate
  4. customevaporated
  5. customA pale brown oil with Rf=0.13 (ethyl acetate/hexane=1:1) is obtained

出典と根拠

ORDレコード
ord-ca110666b0384f00a99ffea359f5cb59
出典データセット
uspto-grants-2003_11
特許番号
US06642239B2

反応ノート

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