Benzeneacetic acid, 2-fluoro- → 2-[(2-fluorophenyl)acetamido]butyric Acid Iso-butyl Ester

HRID 478802

反応式

HRID 478802 の反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=O.[NH2:12][CH:13]([CH2:21][CH3:22])[C:14]([O:16][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:15]>>[CH2:17]([O:16][C:14](=[O:15])[CH:13]([NH:12][C:9](=[O:11])[CH2:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[F:1])[CH2:21][CH3:22])[CH:18]([CH3:19])[CH3:20]

参加物

3

反応物 2

HCID 67979Benzeneacetic acid, 2-fluoro-HCID 13743360Isobutyl 2-aminobutyrate

生成物 1

HCID 536432492-[(2-fluorophenyl)acetamido]butyric Acid Iso-butyl Ester

実験手順

Following General Procedure I above and using 2-fluorophenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure J above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was By filtration as described in the general procedure. NMR data was as follows:

後処理

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas By filtration

出典と根拠

ORDレコード
ord-68c4b4157d714eb5aed1f4de634e96ff
出典データセット
uspto-grants-2003_11
特許番号
US06642261B2

関連ノート

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