Methylhydrazine → 3-tert-Butyl-1-methyl-1H-pyrazol-5-amine

HRID 479258

反応式

HRID 479258 の反応式
[CH3:1][C:2]([CH3:9])([CH3:8])[C:3](=O)[CH2:4][C:5]#[N:6].[CH3:10][NH:11][NH2:12]>C(O)CC>[NH2:6][C:5]1[N:11]([CH3:10])[N:12]=[C:3]([C:2]([CH3:9])([CH3:8])[CH3:1])[CH:4]=1

参加物

4

反応物 2

HCID 6061MethylhydrazineHCID 108871Pentanenitrile, 4,4-dimethyl-3-oxo-

生成物 1

HCID 27352873-tert-Butyl-1-methyl-1H-pyrazol-5-amine収率 65.3%

試薬・触媒・溶媒 1

HCID 10311-Propanol溶媒

実験手順

To a solution of 12.5 g (0.1 mol) of 4,4-dimethyl-3-oxopentanenitrile in 50 cm3 of n-propanol were added, at room temperature, 4.6 g (0.1 mol) of methylhydrazine. The reaction medium was maintained at reflux for 1 hour and then cooled to room temperature. The white solid obtained was filtered off on a sinter funnel and then washed with isopropyl ether. After drying under vacuum at 40° C., 10 g of the expected product were obtained in the form of a beige solid, the melting point of which was 157° C.

後処理

  1. temperatureThe reaction medium was maintained
  2. temperatureat reflux for 1 hour
  3. customThe white solid obtained
  4. filtrationwas filtered off on a sinter funnel
  5. washwashed with isopropyl ether
  6. customAfter drying under vacuum at 40° C.

出典と根拠

ORDレコード
ord-7fcb0b11ed2e4cd290fcef52925a68f6
出典データセット
uspto-grants-2003_11
特許番号
US06645258B2

関連ノート

読み込み中…