Thiophosgene → 2-Chloro-5-isothiocyanatopyridine
反応式
[C:1](Cl)(Cl)=[S:2].[NH2:5][C:6]1[CH:7]=[CH:8][C:9]([Cl:12])=[N:10][CH:11]=1>C(Cl)(Cl)Cl>[Cl:12][C:9]1[CH:8]=[CH:7][C:6]([N:5]=[C:1]=[S:2])=[CH:11][N:10]=1参加物
4
実験手順
A solution of thiophosgene (3.21 mL, 42.1 mmol) in chloroform (10 mL) was heated at reflux and treated with a solution of 5amino-2-chloropyridine (3.61 g, 28.1 mmol) in chloroform (25 mL) for 40 minutes. The solution was heated an additional 2 hours, the reaction mixture was cooled, and the solids formed were removed by filtration. Concentration of the filtrate provided 2.73 g of the desired product as a white solid.
後処理
- temperatureat reflux
- temperatureThe solution was heated an additional 2 hours
- temperaturethe reaction mixture was cooled
- customthe solids formed
- customwere removed by filtration
出典と根拠
- ORDレコード
- ord-76ceb25cf7374bbe9df1b49db161f721
- 出典データセット
- uspto-grants-2003_11
- 特許番号
- US06645968B2
反応ノート
読み込み中…