3-Chloroaniline → (E)-4-chlorostyryl-N-3-chlorophenyl Sulfonamide

反応式

[Cl:1][C:2]1[CH:13]=[CH:12][C:5](/[CH:6]=[CH:7]/[S:8](Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[Cl:14][C:15]1[CH:16]=[C:17]([CH:19]=[CH:20][CH:21]=1)[NH2:18]>>[Cl:1][C:2]1[CH:13]=[CH:12][C:5](/[CH:6]=[CH:7]/[S:8]([NH:18][C:17]2[CH:19]=[CH:20][CH:21]=[C:15]([Cl:14])[CH:16]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1

参加物

反応物 2

HCID 79323-Chloroaniline

HCID 5938154(E)-2-(4-chlorophenyl)ethene-1-sulfonyl chloride

生成物 1

HCID 10131451(E)-4-chlorostyryl-N-3-chlorophenyl Sulfonamide収率 31.8%

実験手順

A solution of (E)-4-chlorostyrylsulfonyl chloride (10 mmol) and 3-chloroaniline (10 mmol) was subjected to General Procedure 1, part B. The title compound, melting point 118-120° C., was obtained in 31.8% yield.

出典と根拠

ORDレコード: ord-b107d3f0dc2d4112831083b3eefe59d9
出典データセット: uspto-grants-2003_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06646009B2

反応ノート

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