2-Ethoxy-5-nitropyridine → 6-Ethoxypyridin-3-amine

HRID 479854

反応式

HRID 479854 の反応式
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-])=O)=[CH:6][N:5]=1)[CH3:2]>C(O)C.[Pd]>[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([NH2:10])=[CH:6][N:5]=1)[CH3:2]

参加物

4

反応物 1

HCID 2958642-Ethoxy-5-nitropyridine

生成物 1

HCID 30403016-Ethoxypyridin-3-amine収率 97.8%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of 2-ethoxy-5-nitropyridine (3.60 g) and 10% Pd/C (360 mg) in ethanol (40 mL) was placed in a Paar bottle and shaken under hydrogen (50 PSI) for 16 h. The mixture was filtered through Celite using dichloromethane and concentrated to give 2.892 g of 2-ethoxy-5-aminopyridine as a gold solid.

後処理

  1. filtrationThe mixture was filtered through Celite
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-ddc9cd74906f4f819961cfa6de89b5d6
出典データセット
uspto-grants-2003_11
特許番号
US06646124B2

関連ノート

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