Sodium Hydroxide → 6-Ethoxy-4-hydroxy-1,5-naphthyridine-3-carboxylic acid
反応式
[CH2:1]([O:3][C:4]1[N:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[C:8]([C:14]([O:16]CC)=[O:15])[C:7]2=[O:19])[CH3:2].[OH-].[Na+]>C(O)C>[CH2:1]([O:3][C:4]1[N:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[C:8]([C:14]([OH:16])=[O:15])[C:7]2=[O:19])[CH3:2]参加物
4
実験手順
A mixture of ethyl 6-ethoxy-4-oxo-1,4-dihydro-1,5-naphthyridine-3-carboxylate (2.98 g), 1N NaOH (50 mL) and ethanol (10 mL) was heated at reflux for 2 h. The reaction mixture was cooled in an ice bath, acidified, and the resulting precipitate collected, rinsed with water and dried to give 2.42 g of 6-ethoxy-4-oxo-1,4-dihydro-1,5-naphthyridine-3-carboxylic acid as a beige solid.
後処理
- temperaturewas heated
- temperatureat reflux for 2 h
- temperatureThe reaction mixture was cooled in an ice bath
- customthe resulting precipitate collected
- washrinsed with water
- customdried
出典と根拠
- ORDレコード
- ord-df0c7c38f8fe4bdf900986e1979d5f3a
- 出典データセット
- uspto-grants-2003_11
- 特許番号
- US06646124B2
反応ノート
読み込み中…