Potassium Nitrate → Ethyl 2,4-difluoro-5-nitrobenzoate
反応式
[F:1][C:2]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5].[N+:14]([O-])([O-:16])=[O:15].[K+]>S(=O)(=O)(O)O>[F:1][C:2]1[CH:12]=[C:11]([F:13])[C:10]([N+:14]([O-:16])=[O:15])=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5]参加物
4
反応条件
- 温度
- 20 °C
実験手順
To a cooled (−5-0° C.) solution of ethyl 2,4-difluorobenzoate (3.4 g; 18.3 mmol) in conc. sulphuric acid (6 ml) was added potassium nitrate (1.94 g; 19.2 mmol) in small portions over one hour −5° C. Following the addition the temperature was allowed to raise to 20° C. over 4.5 hours. The mixture was poured into ice-water with vigorous stirring. The product was filtered off, washed with water and air-dried. Yield: 3.2 g (76%).
後処理
- additionthe addition the temperature
- filtrationThe product was filtered off
- washwashed with water
- customair-dried
出典と根拠
- ORDレコード
- ord-66d8ef6705cf4b33aea0413ca803f65d
- 出典データセット
- uspto-grants-2003_11
- 特許番号
- US06649609B2
反応ノート
読み込み中…