4-Chloroaniline → ethyl acetoacetate, sodium salt

HRID 480068

反応式

HRID 480068 の反応式
ClC1C=CC(N)=CC=1.C([CH:11]([C:17]([CH3:19])=O)[C:12]([O:14][CH2:15][CH3:16])=[O:13])C.Cl.C([OH:23])C>>[O:23]=[C:11]([CH2:17][CH3:19])[C:12]([O:14][CH2:15][CH3:16])=[O:13]

参加物

4

反応物 3

HCID 78124-ChloroanilineHCID 79065Butanoic acid, 2-ethyl-3-oxo-, ethyl esterHCID 21887872Ethanol hydrochloride

生成物 1

HCID 85195ethyl acetoacetate, sodium salt

実験手順

The p-chlorophenylhydrazone of ethyl 2-oxobutanoate was prepared by adaptation of the Japp-Klingemann reaction as described by Lions and Hughes (J. Proc. Roy. Soc. N.S. Wales 1939, 71: 445) to p-chloroaniline and ethyl 2-ethylacetoacetate. This phenylhydrazone was treated with HCl-ethanol according to the procedure of Lions and Hughes (J. Proc. Roy. Soc. N.S. Wales 1939, 71: 445) as applied therein to the corresponding bromophenylhydrazone. The title substance was collected by filtration as an orange solid after suspending the concentrated residue in water.

後処理

  1. filtrationThe title substance was collected by filtration as an orange solid

出典と根拠

ORDレコード
ord-5293d7755e5f4c0ca75af02f1701131b
出典データセット
uspto-grants-2003_11
特許番号
US06649634B2

関連ノート

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