Water → 3-Methyl-1,2-oxazole-4-carboxylic acid

HRID 480088

反応式

HRID 480088 の反応式
[CH3:1][C:2]1[C:6]([C:7]([O:9]CC)=[O:8])=[CH:5][O:4][N:3]=1.O>C(O)C.[OH-].[Na+]>[CH3:1][C:2]1[C:6]([C:7]([OH:9])=[O:8])=[CH:5][O:4][N:3]=1

参加物

5

反応物 2

HCID 962WaterHCID 317668Ethyl 3-methyl-1,2-oxazole-4-carboxylate

生成物 1

HCID 45896923-Methyl-1,2-oxazole-4-carboxylic acid収率 93.9%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

Ethyl 3-methyl-4-isoxazolecarboxylate (1.3 g) is stirred at room temperature overnight in 5 mL of ethanol and 10 mL of 2.5 N sodium hydroxide. Dilution with water, cooling in ice, and acidification to pH 2 with 6 N hydrochloric acid precipitates an off-white solid which is collected by vacuum filtration, washed with ethanol/water, and dried under vacuum to give 1.0 g of 3-methyl-4-isoxazolecarboxylic acid.

後処理

  1. customacidification to pH 2 with 6 N hydrochloric acid precipitates an off-white solid which
  2. filtrationis collected by vacuum filtration
  3. washwashed with ethanol/water
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-f0a771454ca241ffaf8ed8222497cba7
出典データセット
uspto-grants-2003_11
特許番号
US06649635B2

関連ノート

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