Methylamine → 5-chloro-2-methoxy-N-methylbenzenesulfonamide
反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:12][CH3:13])=[C:6]([S:8](Cl)(=[O:10])=[O:9])[CH:7]=1.[CH3:14][NH2:15]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:12][CH3:13])=[C:6]([S:8]([NH:15][CH3:14])(=[O:10])=[O:9])[CH:7]=1参加物
4
実験手順
To a solution of 5-Chloro-2-methoxy-benzenesulfonyl chloride (1.0 g, 4.15 mmol) in tetrahydrofuran(8 ml) was bubbled methylamine gas until saturated. The reaction mixture was sealed with a septa and stirred overnight at ambient temperature. The reaction mixture was then concentrated, triterated in dichloromethane and ether, filtered and dried yielding the above titled compound 1.05 g (>100%) white solid.
後処理
- customThe reaction mixture was sealed with a septa
- concentrationThe reaction mixture was then concentrated
- filtrationether, filtered
- customdried
出典と根拠
- ORDレコード
- ord-13d1c3575f0c4bfea62281d6f1860407
- 出典データセット
- uspto-grants-2003_11
- 特許番号
- US06649611B2
反応ノート
読み込み中…