Hydrochloric Acid → Methyl 3-(2-aminoethyl)benzoate

HRID 480331ノート

反応式

HRID 480331 の反応式
[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][C:11]#[N:12])[CH:5]=1.Cl>CCO.O=[Pt]=O>[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][CH2:11][NH2:12])[CH:5]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 10821136Methyl 3-(cyanomethyl)benzoate

生成物 1

HCID 10511548Methyl 3-(2-aminoethyl)benzoate収率 84.8%

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 702Ethanol溶媒

実験手順

A solution of 3-cyanomethyl-benzoic acid methyl ester (1.36 g) in EtOH (25 mL) was saturated with HCl (g) and PtO2 (200 mg) was added. The reaction was hydrogenated on a Parr shaker at 50 psi for 2.5 h. The catalyst was removed via filtration through Celite and the solvent was removed in vacuo. The resulting solid was stirred in Et2O and the mixture was filtered to yield the title compound as a white solid (1.18 g). MS 180 (M+1).

後処理

  1. additionwas added
  2. customThe catalyst was removed via filtration through Celite
  3. customthe solvent was removed in vacuo
  4. filtrationthe mixture was filtered

出典と根拠

ORDレコード
ord-5b0d8eada1d5469d983210761aa9d363
出典データセット
uspto-grants-2003_11
特許番号
US06649657B2

反応ノート

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