Ethanol → HCID 3045156、化合物

HRID 480422ノート

反応式

HRID 480422 の反応式
[CH3:1][C:2]([CH3:7])([CH3:6])[C:3](=[O:5])[CH3:4].[N:8]1[CH:13]=[CH:12][C:11]([CH:14]=O)=[CH:10][CH:9]=1.C(O)C.[OH-].[Na+]>ClCCl>[C:2]([C:3](=[O:5])[CH:4]=[CH:14][C:11]1[CH:12]=[CH:13][N:8]=[CH:9][CH:10]=1)([CH3:7])([CH3:6])[CH3:1]

参加物

6

反応物 4

HCID 702EthanolHCID 6416PinacoloneHCID 133894-PyridinecarboxaldehydeHCID 14798Sodium Hydroxide

生成物 1

HCID 3045156HCID 3045156、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of 3,3-dimethyl-2-butanone (2.5 ml, 20.0 mmol), 4-pyridinecarboxaldehyde (2.15 ml, 22.3 mmol), ethanol (7.6 ml), and 4.5% aqueous sodium hydroxide (4.6 ml) was kept at room temperature for 12 h. It was diluted with dichloromethane, washed with aqueous hydrochloric acid and water, dried and evaporated. Subsequent column chromatography (hexane-ethyl acetate=3:1) provided the title compound. MS (m/z): 190.4 (M+H)+; C12H15NO requir. 189.3.

後処理

  1. washwashed with aqueous hydrochloric acid and water
  2. customdried
  3. customevaporated

出典と根拠

ORDレコード
ord-36b04c5defaf4828b8bfba1948e3b238
出典データセット
uspto-grants-2003_11
特許番号
US06649604B2

反応ノート

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