3-cyclopropyl-1H-pyrazol-5-amine → HCID 178420515、化合物

HRID 480624

反応式

HRID 480624 の反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH2:12][O:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:3]=1.[NH2:20][C:21]1[CH:25]=[C:24]([CH:26]2[CH2:28][CH2:27]2)[NH:23][N:22]=1>C1COCC1>[CH:26]1([C:24]2[CH:25]=[C:21]([NH:20][C:2]3[C:11]4[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=4)[N:5]=[C:4]([CH2:12][O:13][C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[N:3]=3)[NH:22][N:23]=2)[CH2:28][CH2:27]1

参加物

4

反応物 2

HCID 27580143-cyclopropyl-1H-pyrazol-5-amineHCID 219910934-Chloro-2-phenoxymethylquinazoline

生成物 1

HCID 178420515HCID 178420515、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
65 °C

実験手順

To a solution of the above 4-chloro-2-phenoxymethylquinazoline (0.5 g, 1.85 mmol) in THF (30 mL) is added 3-amino-5-cyclopropylpyrazole (0.47 g, 3.69 mmol) and the reaction mixture is heated at 65° C. for 24 hours. Solvent is evaporated and ethanol is added. A white solid forms and is collected by filtration and dried under vacuum to give (5-cyclopropyl-2H-pyrazol-3-yl)-(2-phenoxymethyl-quinazolin-4-yl)-amine.

後処理

  1. customSolvent is evaporated
  2. additionethanol is added
  3. filtrationA white solid forms and is collected by filtration
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-6f4d5aa3059d4477abb51b1ce1fca777
出典データセット
uspto-grants-2003_11
特許番号
US06653301B2

関連ノート

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