Dibenzyl 3,4,5-trimethoxyphenylphosphonate → 3,4,5-Trimethoxyphenylphosphonic Acid
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([P:13](=[O:30])([O:22]CC2C=CC=CC=2)[O:14]CC2C=CC=CC=2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10]>C(OCC)(=O)C.[Pd]>[CH3:12][O:11][C:7]1[CH:6]=[C:5]([P:13](=[O:14])([OH:30])[OH:22])[CH:4]=[C:3]([O:2][CH3:1])[C:8]=1[O:9][CH3:10]参加物
4
実験手順
To a solution of dibenzyl 3,4,5-trimethoxyphenylphosphonate 2 (1 mmol) in 30 mL of ethyl acetate is added 10% Pd on carbon (0.10 g). The mixture is stirred under an atmosphere of hydrogen for 16 hours. Mixture is filtered through celite and washed with methanol (3×10 mL). All washings and filtrate are combined and concentrated to give 3,4,5-trimethoxyphenylphosphonic acid 3.
後処理
- filtrationMixture is filtered through celite
- washwashed with methanol (3×10 mL)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-2dcfab923fbe41a4835acae0771e351a
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06702705B1
反応ノート
読み込み中…