Sulfuric Acid → Salbutamol

HRID 48093

反応式

HRID 48093 の反応式
S(=O)(=O)(O)O.[Cl-].[Na+].[CH3:8][C:9]([NH:12][CH2:13][CH:14]([OH:24])[C:15]1[CH:16]=[CH:17][C:18]([OH:23])=[C:19]([CH2:21][OH:22])[CH:20]=1)([CH3:11])[CH3:10].OS(O)(=O)=O>O>[CH3:11][C:9]([NH:12][CH2:13][CH:14]([OH:24])[C:15]1[CH:16]=[CH:17][C:18]([OH:23])=[C:19]([CH2:21][OH:22])[CH:20]=1)([CH3:8])[CH3:10]

参加物

5

反応物 3

HCID 1118Sulfuric AcidHCID 5234Sodium ChlorideHCID 9884233Salbutamol Sulfate

生成物 1

HCID 2083Salbutamol

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

In an alternative embodiment, the inhalation solution of the present invention may be prepared as follows: (i) fitting a high density polyethylene (HDPE) or stainless steel formulation tank with a bottom drain and peristaltic recirculation system (for HDPE) or tri-blender (for stainless steel) for mixing; (ii) filling the tank with approximately 90% of the required amount of Purified Water USP at a temperature of between 18° C. to 25° C.; while mixing, (iii) adding sulfuric acid, Sodium Chloride USP, and at least a therapeutically effective pediatric amount of Albuterol Sulfate USP to the tank; (iv) continue mixing until all chemical components are dissolved; (v) adding Purified Water USP to adjust the final volume, if necessary, thus producing an albuterol mixture.

後処理

  1. customIn an alternative embodiment, the inhalation solution of the present invention may be prepared
  2. additionfor mixing
  3. customof between 18° C. to 25° C.
  4. additionwhile mixing
  5. dissolutionare dissolved
  6. customPurified Water USP

出典と根拠

ORDレコード
ord-5e22ad9c5cce42a49be1bce2ca1f9a58
出典データセット
uspto-grants-2004_03
特許番号
US06702997B2

関連ノート

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