Hydrogen Bromide → HCID 69735974、化合物

HRID 481068ノート

反応式

HRID 481068 の反応式
C[O:2][C:3]([C:5]1[C:16]2[C:15]3[N:11]([CH:12]=[CH:13][N:14]=3)[CH2:10][CH2:9][C:8]=2[NH:7][CH:6]=1)=[O:4].[BrH:17]>>[BrH:17].[N:14]1[CH:13]=[CH:12][N:11]2[C:15]=1[C:16]1[C:5]([C:3]([OH:4])=[O:2])=[CH:6][NH:7][C:8]=1[CH2:9][CH2:10]2

参加物

3

反応物 2

HCID 260Hydrogen BromideHCID 20605631HCID 20605631、化合物

生成物 1

HCID 69735974HCID 69735974、化合物

実験手順

A solution of 5,6-dihydro-4H-1,3a,6-triaza-as-indacene-8-carboxylic acid methyl ester (516 mg) and 48% hydrobromic acid (5 mL) is heated at 600 for 60 hours. The mixture is cooled to room temperature and concentrated in vacuo. The residue is slurried with diethyl ether and the ether is decanted off. This is repeated until no more color is visible in the ether layer. The remaining solid is dried in vacuo to give 5,6-dihydro-4H-1,3a,6-triaza-as-indacene-8-carboxylic acid hydrobromide, 350 mg, brown solid: 1H NMR(DMSO-d6) 3.17 (2H, t), 4.40 (2H, t), 7.35 (1H, d), 7.57 (1H, d), 7.63 (1H, s) 12.34 (1H, s), 12.45 (1H, s).

後処理

  1. concentrationconcentrated in vacuo
  2. customthe ether is decanted off
  3. customThe remaining solid is dried in vacuo

出典と根拠

ORDレコード
ord-781abc4d62eb4748be48991a843cbf0c
出典データセット
uspto-grants-2003_11
特許番号
US06653471B2

反応ノート

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