4-Methylmorpholine → Boc-Val-Pro-OBzl

HRID 481260

反応式

HRID 481260 の反応式
[NH:1]1[CH2:15][CH2:14][CH2:13][C@H:2]1[C:3]([O:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:4].[NH:16]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[C@H:17]([C:21](O)=[O:22])[CH:18]([CH3:20])[CH3:19].C1C=CC2N(O)N=NC=2C=1.CN1CCOCC1.C1CCC(N=C=NC2CCCCC2)CC1>C(Cl)(Cl)Cl>[NH:16]([C:24]([O:26][C:27]([CH3:29])([CH3:28])[CH3:30])=[O:25])[C@H:17]([C:21]([N:1]1[CH2:15][CH2:14][CH2:13][C@H:2]1[C:3]([O:5][CH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1)=[O:4])=[O:22])[CH:18]([CH3:19])[CH3:20]

参加物

7

反応物 5

HCID 79724-MethylmorpholineHCID 10868DicyclohexylcarbodiimideHCID 757711-HydroxybenzotriazoleHCID 83693Boc-L-ValineHCID 736155Benzyl L-prolinate

生成物 1

HCID 14304307Boc-Val-Pro-OBzl

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

Boc-Val-Pro-OBzl was prepared by dissolving H-Pro-OBzl (20 g, 83 mmol) in 50 mL of chloroform and adding Boc-Val-OH (18.0 g, 83 mmol), HOBt (23.0 g, 165 mmol), NMM (9.0 mL, 83 mmol) and DCC (17.0 g, 83 mmol). The reaction mixture was stirred overnight at room temperature. The mixture was filtered and solvent was evaporated. Ethyl acetate was added and insoluble material was removed by filtration. The filtrate was washed with 0.2N HCl, 5% NaHCO3, and saturated aqueous NaCl. It was dried over Na2SO4, filtered and evaporate to give a white solid (30 g, 75 mmol, 90%). ESI/MS calculated for C22H32N2O5 +H: 405.2. Found 405.6.

後処理

  1. filtrationThe mixture was filtered
  2. customsolvent was evaporated
  3. additionEthyl acetate was added
  4. custominsoluble material was removed by filtration
  5. washThe filtrate was washed with 0.2N HCl, 5% NaHCO3, and saturated aqueous NaCl
  6. dry with materialIt was dried over Na2SO4
  7. filtrationfiltered
  8. customevaporate

出典と根拠

ORDレコード
ord-467796608f4d401da3bd6403a5daac12
出典データセット
uspto-grants-2003_11
特許番号
US06653295B2

関連ノート

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