Nitrogen mustard hydrochloride → 1-(4-Methylpiperazin-1-yl)naphthalen-2-ol

HRID 481358

反応式

HRID 481358 の反応式
Cl.[NH2:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][C:4]=1[OH:13].Cl.Cl[CH2:16][CH2:17][N:18]([CH2:20][CH2:21]Cl)[CH3:19].C(=O)([O-])[O-].[Na+].[Na+]>C(O)CCC>[CH3:19][N:18]1[CH2:20][CH2:21][N:2]([C:3]2[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[CH:6]=[CH:5][C:4]=2[OH:13])[CH2:16][CH2:17]1

参加物

5

反応物 3

HCID 5935Nitrogen mustard hydrochlorideHCID 10340Sodium CarbonateHCID 5184691-Amino-2-naphthol hydrochloride

生成物 1

HCID 190661661-(4-Methylpiperazin-1-yl)naphthalen-2-ol

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒

実験手順

1-Aminonaphthalen-2-ol hydrochloride (5 g, 25.6 mmol) is brought to the reflux point of 1-butanol (100 ml) in the presence of 2-chloro-N-(chloroethyl)-N-methylethanamine hydrochloride (4.9 g, 25.6 mmol) and sodium carbonate (5.4 g, 51 mmol). After 48 h, the reaction mixture is concentrated and impregnated onto silica and then purified by flash chromatography with a mixture (93/7/1) of dichloromethane/methanol/aqueous ammonia.

後処理

  1. concentrationthe reaction mixture is concentrated
  2. custompurified by flash chromatography with a mixture (93/7/1) of dichloromethane/methanol/aqueous ammonia

出典と根拠

ORDレコード
ord-852d70383fab463598ddab0596238037
出典データセット
uspto-grants-1998_08
特許番号
US05789412

関連ノート

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