Ethanol → 5-methyl-3H-benzofuran-2-one

HRID 481410

反応式

HRID 481410 の反応式
Cl[CH2:2][C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9](=[O:11])[CH2:8][C:7]=2[CH:12]=1.C(O)C>C(O)C.C(OCC)(=O)C.[Pd]>[CH3:2][C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9](=[O:11])[CH2:8][C:7]=2[CH:12]=1

参加物

5

反応物 2

HCID 702EthanolHCID 190662885-chloromethyl-3H-benzofuran-2-one2 回

生成物 1

HCID 100576465-methyl-3H-benzofuran-2-one

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 21584252Ethanol ethylacetate溶媒

実験手順

A solution of the product of Step 1, above (55) (10.89 mmol), in ethanol/ethyl acetate (23 ml/5 ml) was added to 10 ml ethanol over 10% palladium catalyst on carbon (100 mg). The mixture was hydrogenated on a Parr shaker at 45 psi for 2 hours. The reaction mixture was filtered through celite and the organics were concentrated to dryness to obtain the title compound (56).

後処理

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationthe organics were concentrated to dryness

出典と根拠

ORDレコード
ord-bbbe0f91cc634aafa054f649f7c01920
出典データセット
uspto-grants-1998_08
特許番号
US05789415

関連ノート

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