Methyl 2-(4-hydroxy-3-nitrophenyl)acetate → Methyl 2-(3-amino-4-hydroxyphenyl)acetate

HRID 48148

反応式

HRID 48148 の反応式
[CH3:1][O:2][C:3](=[O:15])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]([N+:12]([O-])=O)[CH:6]=1>[Pd].CO>[CH3:1][O:2][C:3](=[O:15])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]([NH2:12])[CH:6]=1

参加物

4

反応物 1

HCID 1473109Methyl 2-(4-hydroxy-3-nitrophenyl)acetate

生成物 1

HCID 1475136Methyl 2-(3-amino-4-hydroxyphenyl)acetate収率 98.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

Methyl(4-hydroxy-3-nitrophenyl)acetate [from step 3] (48.9 g, 0.23 mole) and 5% palladium on carbon were suspended in methanol and the resulting mixture was hydrogenated until all the starting material had been consumed. The reaction mixture was filtered to remove the catalyst and the filtercake was washed with methanol. The combined filtrate and washings were concentrated in vacuo, affording methyl(3-amino-4-hydroxyphenyl)acetate as a solid (41.0 g).

後処理

  1. customhad been consumed
  2. filtrationThe reaction mixture was filtered
  3. customto remove the catalyst
  4. washthe filtercake was washed with methanol
  5. concentrationThe combined filtrate and washings were concentrated in vacuo

出典と根拠

ORDレコード
ord-7084f53764894ab79b3924f11ea5a968
出典データセット
uspto-grants-2004_03
特許番号
US06703347B2

関連ノート

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